The final stage of analyzing designed experiments data is determining the optimal set of process conditions that works for all responses. Stat-Ease software does this via a numerical optimization algorithm. This routine simultaneously optimizes all responses at once, based on goals set by the experimenter. This is achieved by deploying the Derringer-Suich(1) desirability criteria in conjunction with the Nelder-Mead(2) variable-sized simplex search algorithm. This optimization function balances competing response goals to find the “sweet spot” that produces the best of all worlds. Without getting deep into the mathematical weeds of these tools, I would like to provide some basic concepts and discuss how to use this method to optimize DOE results.

**Starting point: minimum model requirements**

Numerical optimization uses prediction models created by the analysis of each measured response. The stronger the prediction models, the more accurate the optimization results. If the analysis does not show a strong relationship between the factors and the response, then optimization will not work well. At a minimum, the model p-value should be less than 0.05, and the model should only include terms that are statistically significant plus those needed to maintain model hierarchy. If the DOE data included replicates, then there should be an insignificant lack of fit test (p-value >0.10). Key summary statistics for modeling include adjusted R-squared and predicted R-squared. Higher is better for each of these, meaning that more variation in the data and in the predictions is explained by the model. There is not a particular “cut-off” for these values but models that explain more than 50% of the variation are going to perform better than those that do not. In summary, start optimization with response models that explain the data and produce reliable predictions.

**Desirability at a specific point**

Numerical optimization is driven by a mathematical calculation called desirability. Points within the design space are evaluated via the desirability function that is defined by the user-specified goals for each response. The overall (multi-response) desirability (D) is the geometric mean of the individual desirability (di) for each response.

*Figure 1: Desirability function*

An individual desirability “little d” (range of 0 to 1) is defined by how closely the evaluated point meets the response goal. Typical response goals are maximize, minimize or target a specific value. In addition to the goal, upper and lower “acceptable” limits on the response values must be set.

Illustration: The experimenters study a process that has 3 input factors and 2 output responses. In this example, the first response (% Conversion) measurements has an observed range of 51-97 percent. The goal for conversion is maximize. Considering business expectations, the minimum acceptable conversion is determined to be 80%, so that is defined as the lower limit. The upper limit is set to the theoretical maximum of 100%. These limits, along with the goal, define the desirability function for the conversion response. When evaluating a particular point in the design space, if the measured conversion is less than 80% (defined lower limit), desirability = 0. If conversion is 80-100%, desirability equals the proportion of the way towards the upper limit (100). Therefore, a conversion of 90 gives d=.5 and a conversion of 95 gives d=0.75. Any point that gives % conversion at 100% or higher will result in d=1.

*Figure 2: Response 1 goal: Maximize with an acceptable range of 80-100%.*

Response 2 is Activity and the goal is a Target of 63 and a range of 60-66 (Figure 3). Desirability will be 1 only at the exact value of 63. Evaluated points that result in activity levels between 60-63 and 63-66 are rated with desirability values that are proportional to the distance from the target. Activity levels that are either below 60 or above 66 are assigned a desirability of 0.

*Figure 3: Response 2 goal: Target 63, with acceptable range 60-66.*

**The optimization algorithm at work**

Once the goals and limits for each response are defined, the search algorithm can start. Stat-Ease software begins with a set of starting points (locations in the design space). For a single starting point, overall desirability (D) is calculated. Then the simplex search starts evaluating desirability (D) in the nearby area and takes “steps” that increase desirability. Steps are taken across the design space until desirability is maximized. All the starting points follow this process, resulting in a set of final “solutions” which are process conditions that at least minimally meet the requirements for all responses (individual desirability is greater than 0).

**Optimization solutions**

If the process is easy to optimize (the responses don’t compete with each other too much), there may be a large robust space that meets the response goals. In this case a very large number of solutions (process conditions) may be found. These solutions are sorted by the desirability value. Common practice is to focus on the top solution(s). Remember however, all the solutions meet the goals set by the experimenter. Optimization does not mean there is a single set of conditions that is best. If the area is very large (many solutions found) then tightening up the upper or lower limits may be merited. There may also be other external criteria to consider such as cost of the solution, manufacturability, ease of implementation, etc. The experimenter should review all the solutions presented and consider which ones make sense from a business perspective.

Figure 4 shows the optimal conditions for the illustration. The red dots show the location of the optimal settings for the factors, within their range. In this case time is set mid-way in the range (47 min), while temperature is maximized at 90 degrees and catalyst is approximately 2.7%. These process conditions are predicted to result in a conversion of 91% and activity level of 63. Confirmation runs should be completed to verify these results.

*Figure 4: Numerical solution “ramps view” for illustration*

*A side note:* Desirability is only a mathematical evaluation tool to compare solutions. Although it ranges from 0 to 1, it is a relative measure within a set of solutions, and not a statistic that needs to be as high as possible. Within a specific DOE, higher desirability means that the solution (set of conditions) met the stated goals more closely than a solution with lower desirability.

**Summary**

The success of numerical optimization starts with strong prediction models from the DOE analysis. Once models are established, the experimenter specifies each response goal, as well as upper and lower limits around that goal. The numerical search algorithm evaluates areas within the design space, searching for areas that simultaneously meet the goals for all the responses. This optimization function balances competing response goals to find the “sweet spot” that produces the best of all worlds.

References:

- G.C. Derringer and R. Suich in “Simultaneous Optimization of Several Response Variables,”
*Journal of Quality Technology*, October 1980, pp. 214-219 *Numerical Recipes in Pascal*by William H. Press et. al., p.326

Thank you to our presenters and all the attendees who showed up to our 2022 Online DOE Summit! We're proud to host this annual, premier DOE conference to help connect practitioners of design of experiments and spread best practices & tips throughout the global research community. Nearly 300 scientists from around the world were able to make it to the live sessions, and many more will be able to view the recordings on the Stat-Ease YouTube channel in the coming months.

Due to a scheduling conflict, we had to move Martin Bezener's talk on "The Latest and Greatest in Design-Expert and Stat-Ease 360." This presentation will provide a briefing on the major innovations now available with our advanced software product, Stat-Ease 360, and a bit of what's in store for the future. Attend the whole talk to be entered into a drawing for a free copy of the book *DOE Simplified: Practical Tools for Effective Experimentation, 3rd Edition**.* New date and time: **Wednesday, October 12, 2022** at 10 am US Central time.

Even if you registered for the Summit already, you'll need to register for the new time on October 12. Click this link to head to the registration page. If you are not able to attend the live session, go to the Stat-Ease YouTube channel for the recording.

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Randomization is essential for success with planned experimentation (DOE) to protect factor effects against bias by lurking variables. For example, consider the 8-run, two-level factorial design shown in Table 1. It lays out the low (−) and high (+) coded levels of each factor in standard, not random, order. Notice that factor C changes level only once throughout the experiment—first being set at the low (minus) level for four runs, followed by the remaining four runs set at the high (plus) level. Now, let’s say that the humidity in the room increases throughout the day—affecting the measured response. Since the DOE runs are not randomized, the change in humidity biases the calculated effect of the non-randomized factor C. Therefore, the effect of factor C includes the humidity change – it is no longer purely due to the change from low to high. This will cause analysis problems!

*Table 1: Standard order of 8-run design*

Randomization itself presents some problems. For example, one possible random order is the classic standard layout, which, as you now know, does not protect against time-related effects. If this unlikely pattern, or other non-desirable patterns are seen, then you should re-randomize the runs to reduce the possibility of bias from lurking variables.

Replicates, such as center points, are used to collect information on the pure error of the system. To optimize the validity of this information, center points should be spaced out over the experimental run order. Random order may inadvertently place replicates in sequential order. This requires manual intervention by the researcher to break up or separate the repeated runs so that each run is completed independently of the matching run.

In both Design-Expert® software and Stat-Ease 360 you can re-randomize by right-clicking on the Run column header and selecting Randomize, as shown in Figure 1. You can also simply edit the Run order and swap two runs by changing the run numbers manually. This is often the easiest method when you want to separate center points, for example.

*Figure 1: Right-click to Randomize*

While randomization is ideal statistically, sometimes it is cumbersome in practice. For instance, temperature can take a very long time to change, so completely randomizing the runs may cause the experiment to go way beyond the time budget. In this case, researchers look for ways to reduce the complete randomization of the design.

I want to highlight a common DOE mistake. An incorrect way to restrict the randomization is to use blocks. Blocking is a statistical technique that groups the experimental runs to eliminate a potential source of variation from the data analysis. A common blocking factor is “day”, setting the block groups to eliminate day-to-day variation. Although this is a form of restricting randomization, if you block on an experimental factor like temperature, then statistically the block (temperature) effect will be removed from the analysis. Any interaction effect with that block will also be removed. The removal of this key effect very likely destroys the entire analysis! Blocking is not a useful method for restricting the randomization of a factor that is being studied in the experiment. For more information on why you would block, see “Blocking: Mowing the Grass in Your Experimental Backyard”.

If factor changes need to be restricted (not fully randomized), then building a split-plot design is the best way to go. A split-plot design takes into account the hard-to-change versus easy-to-change factors in a restricted randomization test plan. Perfect! The associated analysis properly assesses the differences in variation between these two groups of factors and provides the correct effect evaluation. The statistical analysis is a bit more complex, but good DOE software will handle it easily. Split-plot designs are a more complex topic, but commonly used in today’s experimental practices. Learn more about split-plot designs in this YouTube video: Split Plot Pros and Cons – Dealing with a Hard-to-Change Factor.

Randomization is essential for valid and unbiased factor effect calculations, which is central to effective design of experiments analysis. It is up to the experimenter to ensure that the randomization of the experimental runs meets the DOE goals. Manual intervention may be required to separate any replicated points, such as center points. If complete randomization is not possible from a practical standpoint, build a split-plot design that statistically accounts for those restrictions.