This poster displays the abstract and results of an experiment done to optimize enzymatic assays. Experimenters tested buffer, detergent, salt, and cation combinations using a 384-well microtiter plate format. The presence of different detergents and their interactions with different buffers had a profound effect on the enzyme turnover.
Upsher-Smith Laboratories used response surface methods (RSM) to optimize a fluid bed coating process that was producing inconsistent results. Aided by Design-Expert software, scientists discovered a most desirable setup that gave consistent results within specifications with little variability. When transferred to production, the new setup provided excellent results.
A custom rubber molder used DOE to uncover a combination of material selection and manufacturing protocol that created unacceptable results. Armed with this process knowledge, they achieved breakthrough quality improvements.
A major Tier 1 automotive supplier wanted to improve the already high level of quality in their manufacturing process welding nuts to a metal seat frame. They contacted Middle Tennessee State University (MTSU) and requested a design of experiments (DOE) study to determine root causes of torque failures and areas of improvement.
This article demonstrates how to uncover "sweet spots" where multiple fab-process specifications can be met in a most desirable way.
Design of experiments was used for a series of computer simulations to design a new generation of muzzle brakes. DOE saves time by reducing the amount of simulations required and makes it possible to optimize the design with a higher level of certainty.
Mixture DOE catalyzed development of a primer-paint remover that met the requirements of an aircraft manufacturer for environmental safety and speed. The new formulation took only 2 hours to strip off coatings, a huge improvement over competitive products that needed over 8 hours.
MannKind Corporation used designed experiments to identify and optimize critical process variables involved in producing a small molecule substrate for use in pulmonary drug delivery.
In this mini-paper, Mark Anderson details an in-class experiment illustrating the power of two-level factorial design. Also learn how to shoot a wicked slap shot!
This paper details the fabrication of nanoparticles as an example for showing a statistically-rigorous approach to design and analysis of pharmaceutical experiments.