Case Studies and White Papers
Trimming the FAT out of Experimental Methods
This introductory article provides compelling reasons to abandon traditional scientific methods that deploy only one factor at a time (OFAT) in favor of multifactor testing techniques known as design of experiments (DOE). Only via DOE can experimenters detect interactions, which often prove to be the key to success.
An Efficient Approach to Cell Culture Medium Optimization - A Statistical Method to Medium Mixing
Sigma-Aldrich Biotechnology used mixture-DOE to increase cell growth and productivity for a particular recombinant CHO clone. Their simple, yet powerful, media-mixing experiments, combined with DOE software, allowed the researchers to rapidly elucidate an optimal medium mixture.
Reducing 300mm Wafer Coating Defects without Compromising Uniformity
Via a sequential strategy of experimentation using factorial DOE and response surface methods (RSM), engineers at Brewer Science, a microelectronic materials manufacturer, made breakthrough quality improvements in the production of their 300 mm wafers.
PCR Process Optimized via Split-Plot DOE
This paper illustrates the use of design of experiments (DOE) and split-plot design to quickly and effectively determine the factor settings that maximize amplification in a polymerase chain reaction (PCR) experiment.
Design of Experiments Training Banishes Purple-Paper Blues
A paper mill used DOE to pre-define the appearance and shade of paper before full production. They discovered an unexpected interaction takes of a new blue-dye with coating formulation containing a starch binder. It turned the paper purple, which did not happen with a latex binder. This episode formed the basis for a DOE-training exercise.
An innovative blend of hardware, software and the right training in statistical know-how supercharges research automation.
DOE is used in this study demonstrating the versatile compatibility of a unique polyester polyol, PD-90 LV, with both polyester and polyether polyols.
Engineers use mixture design to create thinner, whiter keypad backlighting. A slightly different version was published in Product Design & Development.
Proper application of solder paste onto a PCb is essential in surface mount assemblies. In this case study DOE was used to understand this process, and ultimately to improve electrical yields.
Engineers solved two perplexing wafer production mysteries using design of experiments (DOE), saving the company $180,000 a year.